Zhang Xi – HKU COVID-19 Digital Archives

Zhang Xi

DEPT

State Key Laboratory of Emerging Infectious Diseases

FACULTY

Li Ka Shing Faculty of Medicine

COVID-19 Contribution

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09 Apr 2020
Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus that has resulted in more than 2 000 000 laborator...Read more
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Chu, H
C
Chan, JFW
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Wang, Y
Y
Yuen, TTT
C
Chai, Y
H
Hou, Y
S
Shuai, HV
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Yang, D
H
Hu, B
H
Huang, X
Z
Zhang, X
C
Cai, JP
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Zhou, J
Y
Yuan, S
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Kok, KH
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To, KKW
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Chan, IHY
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Zhang, J
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Sit, KY
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Au, WK
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Yuen, KY
Coronavirus COVID ex vivo interferon SARS
01 Jun 2021
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity
Infection by highly pathogenic coronaviruses results in substantial apoptosis. However, the physiological relevance of apoptosis in the pathogenesis o...Read more
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Chu, H
S
Shuai, HV
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Hou, Y
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Zhang, X
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Wen, L
H
Huang, X
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Hu, B
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Yang, D
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Wang, Y
Y
Yoon, C
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Wong, BHY
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Li, C
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Zhao, X
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Poon, KMV
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Cai, JP
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Wong, KKY
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Yeung, ML
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Zhou, J
A
Au Yeung, KHR
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Yuan, S
J
Jin, D
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Kok, KH
C
Chan, JFW
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Yuen, KY
01 Dec 2021
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and pat...Read more
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Chu, H
H
Hu, B
H
Huang, X
C
Chai, Y
Z
Zhou, DY
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Wang, Y
S
Shuai, HV
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Yang, D
H
Hou, Y
Z
Zhang, X
Y
Yuen, TTT
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Cai, JP
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Zhang, J
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Zhou, J
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Yuan, S
T
To, KKW
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Chan, IHY
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Sit, KY
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Foo, CC
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Wong, YHI
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Ng, ATL
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Cheung, TT
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Law, SYK
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Au, WK
C
Chen, Z
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Kok, KH
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Chan, JFW
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Yuen, KY
01 Jan 2021
SARS-CoV-2 induces a more robust innate immune response and replicates less efficiently than SARS-CoV in the human intestines: An ex vivo study with implications on pathogenesis of COVID-19
Background and Aims: Besides prominent respiratory involvement, gastrointestinal manifestations are commonly reported in Coronavirus Disease 2019 (COV...Read more
C
Chu, H
C
Chan, JFW
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Wang, Y
Y
Yuen, TTT
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Chai, Y
S
Shuai, HV
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Yang, D
H
Hu, B
H
Huang, X
Z
Zhang, X
H
Hou, Y
C
Cai, JP
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Zhang, J
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Zhou, J
Y
Yuan, S
T
To, KKW
H
Hung, FNI
C
Cheung, TT
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Ng, ATL
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Chan, IHY
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Wong, YHI
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Law, SYK
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Foo, CC
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Leung, WK
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Yuen, KY
COVID Immune Activation Intestine Replication SARS
01 Jan 2022
hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs
Host circular RNAs (circRNAs) play critical roles in the pathogenesis of viral infections. However, how viruses modulate the biogenesis of host provir...Read more
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Zhang, X
C
Chu, H
C
Chik, KKH
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Wen, L
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Shuai, HV
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Yang, D
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Wang, Y
H
Hou, Y
Y
Yuen, TTT
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Cai, JP
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Yuan, S
Y
Yuen, KY
C
Chan, JFW
circRNA Coronavirus hnRNP C mRNA RNA binding protein
01 Sep 2020
Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation
Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic virus shedding, nonspecific pharyngitis, to pneumonia with silen...Read more
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Yang, D
C
Chu, H
H
Hou, Y
C
Chai, Y
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Shuai, HV
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Lee, ACY
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Zhang, X
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Wang, Y
H
Hu, B
H
Huang, X
Y
Yuen, TTT
C
Cai, JP
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Zhou, J
Y
Yuan, S
Z
Zhang, J
C
Chan, JFW
Y
Yuen, KY
Coronavirus COVID Dendritic cells Macrophages MDMs moDCs SARS
01 Jul 2020
Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer
Objectives: Respiratory and intestinal tract are two primary target organs of SARS-CoV-2 infection. However, detailed characterization of the host-vir...Read more
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Shuai, HV
C
Chu, H
H
Hou, Y
Y
Yang, D
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Wang, Y
H
Hu, B
H
Huang, X
Z
Zhang, X
C
Chai, Y
C
Cai, JP
C
Chan, JFW
Y
Yuen, KY
COVID IFN Innate immune response SARS

09 Apr 2020

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

01 Jun 2021

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

01 Dec 2021

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

01 Jan 2021

SARS-CoV-2 induces a more robust innate immune response and replicates less efficiently than SARS-CoV in the human intestines: An ex vivo study with implications on pathogenesis of COVID-19

01 Jan 2022

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs

01 Sep 2020

Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation

01 Jul 2020

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer

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