Lau Tsz Kwan Kristy – HKU COVID-19 Digital Archives

Lau Tsz Kwan Kristy

劉子筠

DEPT

Department of Pharmacology and Pharmacy

FACULTY

Li Ka Shing Faculty of Medicine

COVID-19 Contribution

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01 Aug 2022
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong's omicron BA.2 wave: a retrospective cohort study
Background Data on the effectiveness of oral antivirals in patients with mild-to-moderate COVID-19 are urgently needed. This retrospective cohort stu...Read more
W
Wong, CKH
A
Au, CHI
L
Lau, TKK
L
Lau, EHY
C
Cowling, BJ
L
Leung, GM
01 May 2022
Slower Recovery with Early Lopinavir/Ritonavir use in Pediatric COVID-19 Patients: A Retrospective Observational Study
Objectives: There was initially insufficient understanding regarding suitable pharmacological treatment for pediatric Coronavirus Disease 2019 (COVID-...Read more
W
Wong, CKH
L
Low, MCH
K
Kwok, ACY
L
Lui, AYC
L
Lau, TKK
A
Au, CHI
X
Xiong, X
C
Chung, MSH
L
Lau, EHY
C
Cowling, BJ
01 Dec 2022
Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization
Background: Safety after the second dose of the SARS-CoV-2 vaccine remains to be elucidated, especially among individuals reporting adverse events aft...Read more
W
Wong, CKH
X
Xiong, X
L
Lau, TKK
C
Chui, SLC
L
Lai, TTF
L
Li, X
C
Chan, EWY
W
Wan, YFE
A
Au, CHI
C
Cowling, BJ
W
Wong, ICK
14 Jul 2023
Risk of acute liver injury following the nirmatrelvir/ritonavir use
Elevations in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were reported as adverse events of nirmatrelvir/ritonavir users in t...Read more
W
Wong, CKH
M
Mak, LY
A
Au, CHI
C
Cheng, WY
S
So, CH
L
Lau, TKK
L
Lau, EHY
C
Cowling, BJ
L
Leung, GM
Y
Yuen, MF
Hepatology
22 Aug 2021
Optimal timing of remdesivir initiation in hospitalized COVID-19 patients administered with dexamethasone
Background: Evidence is lacking about any additional benefits of introducing remdesivir on top of dexamethasone, and the optimal timing of initiation....Read more
W
Wong, CKH
L
Lau, TKK
A
Au, CHI
X
Xiong, X
C
Chung, MSH
L
Lau, EHY
C
Cowling, BJ
22 Jul 2020
Impact of National Containment Measures on Decelerating the Increase in Daily New Cases of COVID-19 in 54 Countries and 4 Epicenters of the Pandemic: Comparative Observational Study
Background: COVID-19 presents a worldwide epidemic, and various countries have responded differently in terms of containment measures to reduce diseas...Read more
W
Wong, CKH
W
Wong, JYH
T
Tang, HME
A
Au, CHI
L
Lau, TKK
W
Wai, KCA
COVID curfew lockdown national containment stay at home orders
11 May 2022
"Editorial: liver and kidney injury from remdesivir—an issue not as much as its purpose. Authors reply"
W
Wong, CKH
A
Au, CHI
C
Cheng, WY
M
Man, KKC
L
Lau, TKK
M
Mak, LY
C
Chung, MSH
X
Xiong, X
Gastroenterology Hepatology Pharmacology (medical)
19 May 2023
Analysis of All-Cause Hospitalization and Death Among Nonhospitalized Patients With Type 2 Diabetes and SARS-CoV-2 Infection Treated With Molnupiravir or Nirmatrelvir-Ritonavir During the Omicron Wave in Hong Kong
Importance: Diabetes and COVID-19 are both global pandemics, and type 2 diabetes is a common comorbidity in patients with acute COVID-19 and is prove...Read more
L
Lui, TWD
C
Chung, MSH
L
Lau, EHY
L
Lau, TKK
A
Au, CHI
L
Lee, CHP
W
Woo, Yu Cho
W
Wong, CKH
C
Cowling, BJ
03 Oct 2022
HKUMed finds 52% and 66% death reduction for molnupiravir and nirmatrelvir–ritonavir users among inpatients with COVID-19; supports early use of oral antivirals in this population of patients
A research team from HKUMed and D²4H conducted a real-world study on the inpatient use of oral antivirals during a pandemic wave dominated by the Omic...Read more
A
Au, CHI
C
Cowling, BJ
L
Lau, EHY
L
Lau, TKK
L
Leung, GM
W
Wong, CKH
20 Feb 2023
Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study
Background Viral rebound after nirmatrelvir–ritonavir treatment has implications for the clinical management and isolation of patients with COVID-19....Read more
W
Wong, CKH
L
Lau, TKK
A
Au, CHI
L
Lau, EHY
P
Poon, LML
H
Hung, FNI
C
Cowling, BJ
L
Leung, GM
07 Mar 2022
Metformin Use in Relation to Clinical Outcomes and Hyperinflammatory Syndrome Among COVID-19 Patients With Type 2 Diabetes: A Propensity Score Analysis of a Territory-Wide Cohort
Aim: This study was conducted in order to evaluate the association between metformin use and clinical outcomes in type 2 diabetes mellitus (T2DM) pati...Read more
W
Wong, CKH
L
Lui, TWD
L
Lui, AYC
L
Low, MCH
K
Kwok, ACY
L
Lau, TKK
A
Au, CHI
X
Xiong, X
C
Chung, MSH
L
Lau, EHY
C
Cowling, BJ
01 Jul 2022
Remdesivir use and risks of acute kidney injury and acute liver injury among patients hospitalised with COVID-19: A self-controlled case series study
Background and Aim: To investigate and quantify the risks of AKI and ALI associated with remdesivir use, given the underlying diseases of SARS-CoV-2 i...Read more
W
Wong, CKH
A
Au, CHI
C
Cheng, WY
M
Man, KKC
L
Lau, TKK
M
Mak, LY
C
Chung, MSH
X
Xiong, X
L
Lau, EHY
C
Cowling, BJ
21 Jun 2022
Adverse events of special interest and mortality following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines in Hong Kong: A retrospective study
Background Safety monitoring of coronavirus disease 2019 (COVID-19) vaccines is crucial during mass vaccination rollout to inform the choice of vacci...Read more
W
Wong, CKH
L
Lau, TKK
X
Xiong, X
A
Au, CHI
L
Lai, TTF
W
Wan, YFE
C
Chui, SLC
L
Li, X
C
Chan, EWY
G
Gao, L
C
Cheng, FWT
T
Tang, SCW
W
Wong, ICK
01 Jan 2022
Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: propensity score analysis of a territory-wide cohort in Hong Kong
Background and objectives: Type 2 diabetes mellitus (T2DM) patients with Coronavirus Disease 2019 (COVID-19) have poorer prognosis. Inconclusive evide...Read more
W
Wong, CKH
L
Lui, TWD
L
Lui, AYC
K
Kwok, ACY
L
Low, MCH
L
Lau, TKK
A
Au, CHI
X
Xiong, X
C
Chung, MSH
L
Lau, EHY
C
Cowling, BJ
COVID DPP4i Hyperinflammatory syndrome In-hospital death Viral clearance
01 Jun 2023
Real-world effectiveness of nirmatrelvir–ritonavir against BA.4 and BA.5 omicron SARS-CoV-2 variants
W
Wong, CKH
L
Lau, TKK
L
Leung, GM
15 Jul 2021
Clinical Improvement, Outcomes, Antiviral Activity, and Costs Associated With Early Treatment With Remdesivir for Patients With Coronavirus Disease 2019 (COVID-19)
Background: Evidence remains inconclusive on any significant benefits of remdesivir in patients with mild-to-moderate COVID-19. This study explored th...Read more
W
Wong, CKH
L
Lau, TKK
A
Au, CHI
X
Xiong, X
L
Lau, EHY
C
Cowling, BJ
antiviral activity clinical improvement cost COVID Remdesivir
01 Oct 2022
Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study
Background Little is known about the real-world effectiveness of oral antivirals against the SARS-CoV-2 omicron (B.1.1.529) variant. We aimed to asse...Read more
W
Wong, CKH
A
Au, CHI
L
Lau, TKK
L
Lau, EHY
C
Cowling, BJ
L
Leung, GM
01 May 2022
Safety of inactivated and mRNA COVID-19 vaccination among patients treated for hypothyroidism: a population-based cohort study
Background: Thyroiditis and Graves’ disease have been reported after COVID-19 vaccination. We evaluated the risks of adverse events after COVID-19 vac...Read more
X
Xiong, X
W
Wong, CKH
A
Au, CHI
L
Lai, TTF
L
Li, X
W
Wan, YFE
C
Chui, SLC
C
Chan, EWY
C
Cheng, FWT
L
Lau, TKK
L
Lee, CHP
W
Woo, Yu Cho
L
Lui, TWD
W
Wong, ICK

01 Aug 2022

Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong's omicron BA.2 wave: a retrospective cohort study

01 May 2022

Slower Recovery with Early Lopinavir/Ritonavir use in Pediatric COVID-19 Patients: A Retrospective Observational Study

01 Dec 2022

Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization

14 Jul 2023

Risk of acute liver injury following the nirmatrelvir/ritonavir use

22 Aug 2021

Optimal timing of remdesivir initiation in hospitalized COVID-19 patients administered with dexamethasone

22 Jul 2020

Impact of National Containment Measures on Decelerating the Increase in Daily New Cases of COVID-19 in 54 Countries and 4 Epicenters of the Pandemic: Comparative Observational Study

11 May 2022

"Editorial: liver and kidney injury from remdesivir—an issue not as much as its purpose. Authors reply"

19 May 2023

Analysis of All-Cause Hospitalization and Death Among Nonhospitalized Patients With Type 2 Diabetes and SARS-CoV-2 Infection Treated With Molnupiravir or Nirmatrelvir-Ritonavir During the Omicron Wave in Hong Kong

03 Oct 2022

HKUMed finds 52% and 66% death reduction for molnupiravir and nirmatrelvir–ritonavir users among inpatients with COVID-19; supports early use of oral antivirals in this population of patients

20 Feb 2023

Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study

07 Mar 2022

Metformin Use in Relation to Clinical Outcomes and Hyperinflammatory Syndrome Among COVID-19 Patients With Type 2 Diabetes: A Propensity Score Analysis of a Territory-Wide Cohort

01 Jul 2022

Remdesivir use and risks of acute kidney injury and acute liver injury among patients hospitalised with COVID-19: A self-controlled case series study

21 Jun 2022

Adverse events of special interest and mortality following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines in Hong Kong: A retrospective study

01 Jan 2022

Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: propensity score analysis of a territory-wide cohort in Hong Kong

01 Jun 2023

Real-world effectiveness of nirmatrelvir–ritonavir against BA.4 and BA.5 omicron SARS-CoV-2 variants

15 Jul 2021

Clinical Improvement, Outcomes, Antiviral Activity, and Costs Associated With Early Treatment With Remdesivir for Patients With Coronavirus Disease 2019 (COVID-19)

01 Oct 2022

Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study

01 May 2022

Safety of inactivated and mRNA COVID-19 vaccination among patients treated for hypothyroidism: a population-based cohort study

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